Biotin is a B complex vitamin used as a nutritional supplementation for dietary shortage or imbalance which may cause hair loss or total alopecia, brittle nails, skin rash in infants, and mild depression.

Biotin is a form of vitamin B that provides essential nutrients.

Major & minor side effects for Biotin

• Hypersensitivity
• Stomach discomfort and pain
• Skin rash

This medicine is considered safe for consumption by pregnant and breastfeeding women.

Use of this medicine in children should be done only under your doctor's supervision.

The effect of therapy with Biotin may occur 3 to 6 months after starting the therapy.

Dialysis patients may require a higher dose due to drug removal during dialysis.

Calcium Pantothenate is used in a combination with other vitamins to treat vitamin deficiency conditions.

It may also be used in a combination with other vitamins to lower the levels of lipids and cholesterol in the body.

Calcium Pantothenate is the calcium salt of pantothenic acid.

Major & minor side effects for Calcium Pantothenate

• Severe skin rash and hives
• Blistering and peeling of skin
• Difficulty in breathing
• Difficulty in swallowing
• Hoarseness of voice
• Nausea or vomiting
• Diarrhea

This supplement is considered safe for consumption by pregnant and breastfeeding women within the recommended dietary allowance.

Calcium Pantothenate may interact with many other supplements and may cause severe adverse effects. 

This supplement may be prescribed alone or in a combination with other medicines/supplements for a host of other conditions. 

This supplement should be used with caution in patients with an active disorder of the blood like anemia, thrombocytopenia, blood clotting disorders, etc.

This supplement should be used with caution in patients with a history of any gastrointestinal disorders due to the increased risk of severe adverse effects.

It is recommended to first make a dietary modification to treat the deficiency of pantothenic acid.

• Folic acid is the synthetic form of folate, which is a naturally occurring B vitamin. Folate helps make DNA and other genetic material. It is especially important in prenatal health.
• Folate, also called vitamin B-9, is a B vitamin that naturally occurs in certain foods. Folic acid is the form of folate that manufacturers add to vitamin supplements and fortified foods.

• It helps the body make healthy new red blood cells.
• In its deficiency a person can develop anemia, leading to fatigue, weakness, and a pale complexion.
• It leads to folate deficiency anemia.
• Folate is also important for the synthesis and repair of DNA and other genetic material.
• It is particularly important to get during pregnancy. Folate deficiency during pregnancy can lead to neural tube irregularities, such as spina bifida and anencephaly.
• Folic acid is crucial for early fetal development.
• Neural tube irregularities - Taking folic acid supplements before and during pregnancy will help prevent neural tube irregularities in the fetus.
• It may also reduce the risks of preterm birth, heart irregularities, and cleft palate, among other things.
• Depression - Taking folic acid supplements could make depression medications more effective.
• The Office on Women’s Health recommend that women who are or might become pregnant take 400–800 mcg of folic acid per day, and that people with spina bifida or a family history of neural tube irregularities take 4,000 mcg per day. Those who are breastfeeding should aim to take around 500 mcg per day.
• The body absorbs folic acid from supplements and fortified foods better than the folate from naturally occurring foods.

Skin reactions, seizures, gases problem, diarrhea, irritability, confusion, stomach upset, loss of appetite, and hypersensitivity

It is important to note that folic acid can interact with certain medications.

A person should speak to a doctor before taking folic acid if they have any of the following:

• Epilepsy
• Type 2 diabetes
• Rheumatoid arthritis
• Lupus
• Inflammatory bowel disease (ibd)
• Celiac disease

People undergoing kidney dialysis may also wish to avoid taking folic acid.

Inositol is a vitamin-like substance. It is found in many plants and animals. It is also
produced in the human body and can be made in a laboratory.
Inositol can be found in many forms (called isomers). The most common forms are
myo-inositol and D-chiro-inositol.

Inositol is used to for metabolic syndrome and polycystic ovary syndrome (PCOS).
It is also used as a complementary therapy for metabolic and mood disorders.
Inositol has also been found to reduce psoriasis symptoms in people taking lithium,
a drug commonly prescribed to treat bipolar disorder, depression, schizophrenia,
and eating disorders.

 Nausea
 Stomach pain
 Tiredness
 Headache
 Dizziness

The metabolic effects of Inositol may not be appropriate for everyone. Even in
people with diabetes, the prolonged use or overuse of inositol may lead
to hypoglycemia(low blood sugar).
There is also some concern that high doses of inositol hexaphosphate may reduce
the body's ability to absorb zinc, calcium, iron, and other essential minerals,
triggering a nutritional deficiency even if you're eating a balanced diet.

• METHYLSULFONYLMETHANE (MSM) is an herbal product or dietary supplement.
• Methyl Sulfonyl Methane is a non-steroidal anti-inflammatory drugs (NSAID). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Some believe that the substance can treat a wide range of health problems, mostnotably arthritis.

Methylsulfonylmethane is used in the treatment of various conditions such as osteoarthritis, tendinitis, musculoskeletal pain, rheumatoid arthritis etc. It is generally used in combination with other medicines for a more effective treatment.

• Diarrhea or constipation
•  Nausea
•  Bloating
•  Headache
•  Fatigue
•  Insomnia

• Take it with food or milk to prevent upset stomach.
•  Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems.
•  Inform your doctor if you have a history of heart disease or stroke.
•  Avoid consuming alcohol while taking Methyl Sulfonyl Methane as it can increase your risk of stomach problems.
•  Your doctor may regularly monitor your kidney function, liver function and levels of blood components if you are taking this medicine for long-term treatment.
•  This supplement is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

N-acetyl cysteine is most commonly used by mouth for cough and other lung conditions. It is also used for flu, dry eye, and many other conditions, but there is no good scientific evidence to support many of these uses.

N-acetyl cysteine comes from the amino acid L-cysteine. Amino acids are the building blocks of proteins. N-acetyl cysteine has many uses as medicine.

Major & minor side effects for Acetylcysteine

• Nausea and Vomiting
• Fever
• Runny Nose
• Diarrhea
• Abdominal pain
• Skin irritation and rahses
• Throat irritation
• Drowsiness
• Chest tightness
• Hives and wheezing
• Difficulty in breathing
• Presence of blood in cough
• Injection site pain
• Cool and moist skin
• Swelling and soreness of the inside of the mouth

This medicine is not recommended for use in pregnant and breastfeeding women unless clearly necessary. 

This medicine is not recommended for use in patients suffering from a severe and sudden attack of asthma. 

This medicine should not be used with topical antibiotics for relieving dry eye syndrome due to the increased risk of severe adverse reactions.

Both the oral and intravenous forms of this medicine are used for the treatment of paracetamol poisoning.

Use of this medicine may cause severe allergic reactions like a rapid fall in blood pressure, difficulty in breathing, rash, etc. 

Omega-3 fatty acids can improve your cardiovascular health.

Omega-3 fatty acids are a type of fat the body cannot make on its own. They are an essential fat, which means they are needed to survive.

Major &Minor side effects of Omega -3 fatty acid

• Raise levels of high-density lipoprotein (HDL/“good” cholesterol).
• Lower blood pressure.
• burping.
• heartburn.
• stomach pain or discomfort.
• joint pain.
• vomiting.
• constipation.
• diarrhea.
• nausea.

Before taking omega-3 fatty acids, tell your doctor if you are allergic to them; or to fish; or if you have any other allergies.

This product may contain inactive ingredients (such as peanut/soy), which can cause allergic reactions or other problems.

During pregnancy, this medication should be used only when clearly needed.

Proanthocyanidin is used in the treatment of varicose veins.

Proanthocyanidin is a polyphenolic compound that is extracted from grape seeds. It is an antioxidant with anti-inflammatory and vasodilating properties. It helps to dilate the constricted blood veins to reduce the tension on the blood vessels to restore normal blood flow. This is how it works to treat the symptoms of varicose veins such as itching, heaviness, swelling, and pain.

Major & minor side effects for Proanthocyanidin

• Nausea,
• Allergic reaction
• Dizziness
• Headache
• Indigestion

Proanthocyanidins is contraindicated in patients with uncontrolled or untreated hypertension and bleeding disorders

Isoflavones are considered a type of nutritional supplement produced almost
exclusively by the Fabaceae (Leguminosae or bean) family.
Isoflavones are considered phytoestrogens, meaning that they are similar in
structure to the female hormone, estrogen. Isoflavones are also considered anti-
oxidant compounds. This means that they reduce damage due to oxygen (such as
that caused by free radicals) and may help fight against certain types of cancer.

 Isoflavone supplements for menopausal symptoms, some benefit has been
shown, such as improving fatigue and irritability and decreasing hot flashes.
 The clinical research evidence strongly suggests that isoflavones from soy
reduce bad cholesterol called LDL.
 Eating soy protein or fermented soy may reduce blood sugar in those with
diabetes.
 Eating soy may lower the blood pressure slightly and is suggested for those
with slight increases in blood pressure, but NOT in people with severely
elevated blood pressure.
 Soy formula supplementation may shorten the duration of diarrhea
 soy protein from food sources and isoflavones in supplement form were both
found to increase bone density.
 Many health experts feel that eating fermented soy in moderation may:
 Increase bone density
 Help to prevent breast and uterine cancers
 Lower the incidence of prostate cancer
 Lower bad cholesterol levels
 Improve mental functioning
 Reduce muscle soreness (particularly after exercise)

 GI upset
 Constipation,
 Bloating and nausea

 Allergic reactions (involving rash, itching, and in severe instances,
anaphylaxis)
 Loss of appetite
 Swelling in ankle and abdominal tenderness

 Long-term use of soy extract supplements may result in abnormal tissue
growth in the uterus.
 Children should not eat soy in large amounts.
 Those with asthma or hay fever may have a higher risk of an allergic reaction
to soy. 
 Children with cystic fibrosis should avoid taking isoflavones because they
may interfere with the way these kids process protein.
 Those with kidney stones should avoid taking soy isoflavones as they may
increase a chemical, called oxalates, that contributes to kidney stones.
 Hypothyroidism may be worsened when using soy isoflavones.

Vitamin C consists of a water-soluble vitamin known as vitamin C. Vitamin C is also known as L-ascorbic acid or ascorbate.  It occurs as a white or slightly yellow crystal or powder with a slightly acidic taste. On exposure to light, it gradually darkens. In the dry state, it is reasonably stable in air, but in solution, it rapidly oxidizes.

• Vitamin C helps in the growth and repair of tissues of bones, cartilage, tendons, skin, hair, muscles and many more.
• Along with that, it helps in wound healing and also enhances the absorption of iron in our body.
• Excess of free radicals can speed up the ageing process, vitamin C due to its rich antioxidant properties help to reduce the harmful effects of these free radicals. Vitamin C is very crucial for bone and teeth health.
• It improves vision and also regulates blood cholesterol levels.
• Owing to its numerous benefits, it is very important to take an adequate amount of vitamin C in your diet.

Possibly Effective for

• An eye disease that leads to vision loss in older adults (age-related macular degeneration or AMD).
• Irregular heartbeat (atrial fibrillation). Taking vitamin C before and for a few days after heart surgery helps prevent irregular heartbeat after heart surgery.
• Emptying the colon before a colonoscopy.
• Limb pain that usually occurs after an injury (complex regional pain syndrome). 
• Skin redness caused by injury or irritation (erythema). Using a skin cream containing vitamin C might decrease skin redness following laser resurfacing for scar and wrinkle removal.
• Airway infections caused by exercise. Using vitamin C before heavy physical exercise, such as a marathon, might prevent upper airway infections that can occur after heavy exercise.
• Swelling (inflammation) of the stomach (gastritis). Some medicine used to treat H. pylori infection can worsen stomach inflammation. Taking vitamin C along with one of these medicines called omeprazole might decrease this side effect.
• A condition in which red blood cells are broken down faster than they are made (hemolytic anemia). Taking vitamin C supplements might help manage anemia in people undergoing dialysis.
• High cholesterol. Taking vitamin C might reduce low-density lipoprotein cholesterol in people with high cholesterol.
• Lead poisoning. Consuming vitamin C in the diet seems to lower blood levels of lead.
• Osteoarthritis. Taking vitamin C from dietary sources or from calcium ascorbate supplements seems to prevent cartilage loss and worsening of symptoms in people with osteoarthritis.
• Pain after surgery. Taking 2 grams of vitamin C by mouth one hour before surgery might reduce pain and the need for opioid pain relievers after surgery. 
• Wrinkled skin. Skin creams containing vitamin C seem to improve the appearance of wrinkled skin. A vitamin C patch also seems to help reduce wrinkles.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Vitamin C and call your doctor at once if you have:

• Joint pain, weakness or tired feeling, weight loss, stomach pain;
• Chills, fever, increased urge to urinate, painful or difficult urination; or
• Severe pain in your side or lower back, blood in your urine.

Common side effects may include:

• Heartburn, upset stomach; or

• Nausea, diarrhoea, stomach cramps.

• Transient mild soreness may occur at the site of intramuscular or subcutaneous injection.
• Too-rapid intravenous administration of the solution may cause temporary faintness or dizziness.
• Although vitamin C is generally considered safe, high doses can cause adverse effects, including heartburn, nausea, headaches, stomach cramps, and diarrhoea.
• Vitamin C is not stored in the body. If you take more than you need, the extra vitamin C will pass into your urine.
• Very large doses may also interfere with tests for sugar in diabetics and with tests for blood in the stool.

Generic Name: cholecalciferol 

Vitamin D3 is needed for normal absorption of calcium and phosphorus, which is further utilized for development and maintenance of bones and teeth. This makes bones stronger and reduces risk for bone fractures.  Vitamin D3 also has a role in ones nerve, muscle, and immune systems.

People who might need extra vitamin D3 include

•  Older adult
•  Breastfed infants
•  People with dark skin
•  People with certain conditions, such as liver diseases, cystic fibrosis and Crohn's disease
•  People who have obesity or have had gastric bypass surgery

Symptoms of vitamin D3 deficiency include bone pain, muscle weakness, fatigue, and mood changes. Vitamin D3 is used for treating osteoporosis, rickets, osteomalacia, renal osteodystrophy and hypoparathyroidism.

•   nausea
•       vomiting
•         constipation
•         weight loss
•        weakness
•         increased calcium levels (hypercalcemia)

May cause allergic reactions or other problems if contain inactive ingredients such as peanut/soy. Pregnant women or Breastfeeding mothers need to consult their doctors before taking Vitamin D3 supplements.

• Vitamin E is essential to the normal functioning of the human body. It plays a central role in your immune system and functions as an antioxidant, neutralizing free radicals that damage cells at the genetic level.
• Vitamin E is fat-soluble, meaning that it is dissolved in fat and able to be stored in the liver and fatty tissues of the body.
   

• Vitamin E acts as an antioxidant (i.e., an inhibitor of oxidation processes) in body tissues. It protects unsaturated fats in the body from oxidation by peroxides and other free radicals.  It also acts as an protection of polyunsaturated fatty acids, cell membranes.
• The vitamin is used commercially as an antioxidant to retard the rancidification of fats, especially vegetable oils.
• Vitamin E aids in the transmission of electrical signals between nerve cells (neurons) of the brain and body.
• Vitamin E is integral to eye health, aiding in the self-repair of the retina, cornea, and uvea (the pigmented portion of the eye).
• Vitamin E can aid in scar healing by hydrating the skin, inhibiting collagen production, and reducing inflammation that can lead to tissue damage.
   

Vitamin E supplements rarely cause any harm if taken at the recommended daily dose.
But sometimes lower doses can trigger side effects like

•  nausea,
•  vomiting,
•  stomach pain,
•  diarrhea.
•  Slow down blood clotting

• Vitamin E deficiency is considered rare in the developed world, except in premature babies with low birth weight or in people with rare genetic disorders such as abetalipoproteinemia or ataxia with vitamin E deficiency.
• VitaminE can neither treat nor prevent liver disease but may help slow its progression.
• VitaminE can slow blood clotting and may need to be avoided in people taking blood thinners like Coumadin (warfarin) or Plavix (clopidogrel).
• VitaminE supplements should also be avoided in people with a history of heart attacks, stroke, bleeding disorders, or head and neck cancers.
• VitaminE supplements are presumed to be safe during pregnancy and breastfeeding.