Lycopene is a powerful antioxidant that may help protect cells from damage. Hence, it is used for high blood pressure, high cholesterol, cancer, and many other conditions.

Used to treat prostate cancer, leukoplakia, asthma and heart disease.

Discoloration of the skin - Lycopenemia

•  Avoid if pregnant
•  It might increase the risk of bleeding during and after surgery. Stop using lycopene supplements at least 2 weeks before a scheduled surgery.
•  Those taking medication for low blood pressure should not take lycopene.

• Ginkgo biloba is an antioxidant-rich herb used to enhance brain health and treat a variety of conditions.
• Ginkgo contains numerous flavonoids, compounds which proponents suggest can protect against aging-related issues such as dementia by improving blood flow to the brain, among other benefits.

• Ginkgo biloba is said to aid in the treatment or prevention of the following health problems:
• Age-related macular degeneration, Alzheimer's disease, Anxiety, Asthma, Bronchitis, Depression, Erectile dysfunction, Fatigue, Glaucoma, High blood pressure, Insulin resistance, Multiple sclerosis, Peripheral artery disease, Sexual dysfunction in women, Tinnitus.

•  Palpitations
•  Bleeding disorder
•  Dizziness
•  Gastrointestinal discomfort
•  Headache
•  Hypersensitivity

• Patients with blood circulation disorders or individuals on anticoagulants, such as aspirin, are at risk of experiencing undesirable effects after taking ginkgo.
• Those taking selective serotonin reuptake inhibitors (SSRI) as antidepressants should not take ginkgo as it inhibits monoamine oxidase, reducing the effectiveness of the medications.
• Combining the two may also increase the risk of a potentially fatal condition known as serotonin syndrome. 
• Gingko can also exaggerate both the good and bad effects of another type of antidepressant, known as monoamine oxidase inhibitors (MAOIs).
• Ginkgo leaves contain long-chain alkylphenols, which are highly allergenic. People who are allergic to poison ivy and other plants with alkylphenols should completely avoid taking ginkgo.
• Eating raw or roasted ginkgo seeds can be poisonous and may lead to serious sideeffects.

Evening primrose oil has long been used by women to treat hot flashes during menopause.

Evening primrose oil was heavily touted as an effective treatment for eczema

Evening primrose, borage seed, or blackcurrant seed oil provided "moderate" relief of pain and disability in people with rheumatoid arthritis.

Evening primrose oil was first proposed as a possible treatment of diabetic neuropathy

an often debilitating nerve pain mainly affecting the feet and legs.

Evening Primrose Oil is a herbal medicine. Its seeds contain high amount of omega-6 essential fatty acids (EFAs), which have an indirect effect on different glands. This helps to regulate hormones during monthly period and breast feeding. It also helps in reducing pain in the breast.

Major & minor side effects for Evening primrose oil

• upset stomach
• nausea
• diarrhea
• headache

Taking evening primrose oil in limited quantity is safe for pregnant and breastfeeding women. 

It is also safe when applied to the skin.

It should not be taken by patients who have bleeding disorder for increased chance of bruising and bleeding.

There is a concern that taking evening primrose might make seizures more likely in some people.

It should not be used by Schizophrenic patients.

Evening primrose might increase the chance of bleeding during or after surgery.

• Folic acid is the synthetic form of folate, which is a naturally occurring B vitamin. Folate helps make DNA and other genetic material. It is especially important in prenatal health.
• Folate, also called vitamin B-9, is a B vitamin that naturally occurs in certain foods. Folic acid is the form of folate that manufacturers add to vitamin supplements and fortified foods.

• It helps the body make healthy new red blood cells.
• In its deficiency a person can develop anemia, leading to fatigue, weakness, and a pale complexion.
• It leads to folate deficiency anemia.
• Folate is also important for the synthesis and repair of DNA and other genetic material.
• It is particularly important to get during pregnancy. Folate deficiency during pregnancy can lead to neural tube irregularities, such as spina bifida and anencephaly.
• Folic acid is crucial for early fetal development.
• Neural tube irregularities - Taking folic acid supplements before and during pregnancy will help prevent neural tube irregularities in the fetus.
• It may also reduce the risks of preterm birth, heart irregularities, and cleft palate, among other things.
• Depression - Taking folic acid supplements could make depression medications more effective.
• The Office on Women’s Health recommend that women who are or might become pregnant take 400–800 mcg of folic acid per day, and that people with spina bifida or a family history of neural tube irregularities take 4,000 mcg per day. Those who are breastfeeding should aim to take around 500 mcg per day.
• The body absorbs folic acid from supplements and fortified foods better than the folate from naturally occurring foods.

Skin reactions, seizures, gases problem, diarrhea, irritability, confusion, stomach upset, loss of appetite, and hypersensitivity

It is important to note that folic acid can interact with certain medications.

A person should speak to a doctor before taking folic acid if they have any of the following:

• Epilepsy
• Type 2 diabetes
• Rheumatoid arthritis
• Lupus
• Inflammatory bowel disease (ibd)
• Celiac disease

People undergoing kidney dialysis may also wish to avoid taking folic acid.

Biotin is a B complex vitamin used as a nutritional supplementation for dietary shortage or imbalance which may cause hair loss or total alopecia, brittle nails, skin rash in infants, and mild depression.

Biotin is a form of vitamin B that provides essential nutrients.

Major & minor side effects for Biotin

• Hypersensitivity
• Stomach discomfort and pain
• Skin rash

This medicine is considered safe for consumption by pregnant and breastfeeding women.

Use of this medicine in children should be done only under your doctor's supervision.

The effect of therapy with Biotin may occur 3 to 6 months after starting the therapy.

Dialysis patients may require a higher dose due to drug removal during dialysis.

Generic Name: cholecalciferol 

Vitamin D3 is needed for normal absorption of calcium and phosphorus, which is further utilized for development and maintenance of bones and teeth. This makes bones stronger and reduces risk for bone fractures.  Vitamin D3 also has a role in ones nerve, muscle, and immune systems.

People who might need extra vitamin D3 include

•  Older adult
•  Breastfed infants
•  People with dark skin
•  People with certain conditions, such as liver diseases, cystic fibrosis and Crohn's disease
•  People who have obesity or have had gastric bypass surgery

Symptoms of vitamin D3 deficiency include bone pain, muscle weakness, fatigue, and mood changes. Vitamin D3 is used for treating osteoporosis, rickets, osteomalacia, renal osteodystrophy and hypoparathyroidism.

•   nausea
•       vomiting
•         constipation
•         weight loss
•        weakness
•         increased calcium levels (hypercalcemia)

May cause allergic reactions or other problems if contain inactive ingredients such as peanut/soy. Pregnant women or Breastfeeding mothers need to consult their doctors before taking Vitamin D3 supplements.