Coenzyme Q10 is most commonly used for conditions that affect the heart such as heart failure and fluid build up in the body, chest pain, and high blood pressure. It is also used for preventing migraine headache, Parkinson disease, and many other conditions.

Coenzyme Q10 is a vitamin-like substance found throughout the body, but especially in the heart, liver, kidney, and pancreas.

Major &Minor side effects of Coenzyme Q10

• Stomach upset
• Nausea
• Loss of appetite
• Vomiting
• Diarrhea
• Allergic skin rashes
• Low blood pressure

This medicine is safe when taken by mouth appropriately during pregnancy.

This medicine is safe to be taken by children under medical supervision.

People undergoing chemotherapy with a class of drugs called alkylating agents should use coenzyme Q10 with caution.

Coenzyme Q10 might lower blood pressure.

Cigarette smoking depletes the amount of coenzyme Q10 stored by the body.

Coenzyme Q10 might interfere with blood pressure control during and after surgery.

Lycopene is a powerful antioxidant that may help protect cells from damage. Hence, it is used for high blood pressure, high cholesterol, cancer, and many other conditions.

Used to treat prostate cancer, leukoplakia, asthma and heart disease.

Discoloration of the skin - Lycopenemia

•  Avoid if pregnant
•  It might increase the risk of bleeding during and after surgery. Stop using lycopene supplements at least 2 weeks before a scheduled surgery.
•  Those taking medication for low blood pressure should not take lycopene.

• Zinc oxide is an inorganic compound with the formula ZnO. ZnO is a white powder that is insoluble in water.
• Zinc (Topical) is a mild antiseptic with skin soothing properties.It works by forming a barrier on the skin to protect it from irritants/moisture

• Zinc oxide topical (for the skin) is used to treat diaper rash, minor burns, severely chapped skin, or other minor skin irritations.
• Zinc oxide rectal suppositories are used to treat itching, burning, irritation, and other rectal discomfort caused by hemorrhoids or painful bowel movement

• Hives
• Itching
• Skin rash
• Worsening of diaper rash
• Burning and stinging of broken skin
• Swelling of the face, lips or tongue.

• If you or your child's symptoms do not improve within 7 days, or if they become worse, check with your doctor.
• If you or your child accidentally swallows the medicine, call the Poison Control Center right away.
• This product may contain inactive ingredients, which can cause allergic reactions or other problems. 

• Selenium is used in the treatment of natural deficiency.
• Selenium is essential for the conversion of thyroxine (T4) to the biologically active thyroid hormone triiodothyronine (T3) thereby it is important in thyroid hormone functioning.
• Selelium is not produced in the body but is needed for the proper immune system and thyroid function.
• It is found in soil, water and some food.

• Selelium is a powerful mineral. It plays a key role in metabolism and the functioning of the Thyroid glands.
• Selenium has antioxidant properties.
• Selenium is used to cure Prostate cancer.
• Some of the diseases due to deficiency of selelium are HIV, Crohn’s disease.
• It is also used to treat diseases like Asthma, Arthritis, Dandruff and Infertility.

• Selenium deficiency produces biochemical changes that might predispose people who experience additional stresses to develop certain illnesses.
• Side effects may include fingernail loss, skin rash, fatigue, irritability and weight loss.

It is observed that overdose of Selelium may increase the chances of non- melanoma (Skin cancer).

Vitamin B12 is used in the treatment of vitamin B12 deficiency.

Vitamin B12 is a nutrient which the body requires in small amounts to make red blood cells, generate energy, and keep nerve cells healthy.

• Symptoms of Vitamin B12 Deficiency
• Weakness, tiredness, or lightheadedness
• Anemia
• Heart palpitations and shortness of breath
• Pale skin
• A smooth tongue
• Constipation, diarrhea, loss of appetite, or gas 
• Nerve problems like numbness or tingling, muscle weakness, and problems walking
• Vision loss
• Mental problems like depression, memory loss, or behavioral changes 

• Most people can prevent vitamin B12 deficiency by eating enough meat, poultry, seafood, dairy products, and eggs.
• If you don't eat animal products, or you have a medical condition that limits how well your body absorbs nutrients, you can take vitamin B12 in a multivitamin or other supplement and foods fortified with vitamin B12.

• Folic acid is the synthetic form of folate, which is a naturally occurring B vitamin. Folate helps make DNA and other genetic material. It is especially important in prenatal health.
• Folate, also called vitamin B-9, is a B vitamin that naturally occurs in certain foods. Folic acid is the form of folate that manufacturers add to vitamin supplements and fortified foods.

• It helps the body make healthy new red blood cells.
• In its deficiency a person can develop anemia, leading to fatigue, weakness, and a pale complexion.
• It leads to folate deficiency anemia.
• Folate is also important for the synthesis and repair of DNA and other genetic material.
• It is particularly important to get during pregnancy. Folate deficiency during pregnancy can lead to neural tube irregularities, such as spina bifida and anencephaly.
• Folic acid is crucial for early fetal development.
• Neural tube irregularities - Taking folic acid supplements before and during pregnancy will help prevent neural tube irregularities in the fetus.
• It may also reduce the risks of preterm birth, heart irregularities, and cleft palate, among other things.
• Depression - Taking folic acid supplements could make depression medications more effective.
• The Office on Women’s Health recommend that women who are or might become pregnant take 400–800 mcg of folic acid per day, and that people with spina bifida or a family history of neural tube irregularities take 4,000 mcg per day. Those who are breastfeeding should aim to take around 500 mcg per day.
• The body absorbs folic acid from supplements and fortified foods better than the folate from naturally occurring foods.

Skin reactions, seizures, gases problem, diarrhea, irritability, confusion, stomach upset, loss of appetite, and hypersensitivity

It is important to note that folic acid can interact with certain medications.

A person should speak to a doctor before taking folic acid if they have any of the following:

• Epilepsy
• Type 2 diabetes
• Rheumatoid arthritis
• Lupus
• Inflammatory bowel disease (ibd)
• Celiac disease

People undergoing kidney dialysis may also wish to avoid taking folic acid.