• Methylcobalamin/Mecobalamin is a form of vitamin B12 that restores its level in the body thereby helping in treating certain anaemias and nerve problems.
• It is required for the integrity of myelin, neuronal function, proper red blood cell formation and DNA synthesis

• It is used to treat Vitamin B12 deficiency in people with Pernicious Anemia.
• It is a beneficial drug to most of the common disorders like cardiovascular disorders, diabetes, anaemia, hyperhomocysteinemia and degenerative disorders.
• Methylcobalamin helps in the synthesis of neuronal lipids, regeneration of axonal nerves and has neuroprotective activity, which promotes neurons to function properly and thus improves Alzheimer disease, Parkinsonism, Dementia and neuropathic syndromes.
• It is an approved treatment for peripheral neuropathy.
• It also helps in balancing the levels of homocysteine, which is produced in excess can cause inflammation of blood vessels.

• Nausea and vomiting
• Diarrhoea
• Decreased appetite
• Dizziness
• Headache
• Skin rash
• Chest pain and discomfort

• Methylcobalamin can show some serious side effects in patients who might suffer from other conditions.
• Everyone needs to consume this medicine only after clinical consultation. The serious side effects of Methylcobalamin can include the formation of clots in limbs, depleted levels of potassium in the blood, a buildup of fluid in the lungs, heart failure and in some cases, anaphylactic reactions such as swollen tongue and throat, and hives.
• Consuming Methylcobalamin is not advisable for patients suffering from optic atrophy, which is a nerve condition that affects the eye.
• People who are suffering from infections or patients who have a low iron level in their body should be careful before taking Methylcobalamin and should only do so after the consultation of the doctor.
• It is not advised for mothers to consume Methylcobalamin if they are breastfeeding. Mother’s milk is a rich source of Vitamin B12 and consuming additional supplements while breastfeeding can have adverse effects on the baby.

Gabapentin’s primary use is to prevent or control seizures.

Gabapentin can also help reduce post-herpetic neuralgia, a burning or stabbing nerve pain that is a common complication of shingles.

Extended-release gabapentin (Horizant) tablets can treat restless legs syndrome.

Gabapentin is an anticonvulsant medication. When given for epilepsy, it is believed to work by reducing the abnormal electrical activity in the brain, thus preventing seizures.

It is also used to treat nerve pain where it blocks pain by interfering with pain signals travelling through the damaged nerves and the brain.

Major & minor side effects for Gabapentin

• Dizziness
• Uncontrolled eye movements
• Agitation and anxiety
• Restlessness
• Hyperactivity
• Unusual tiredness and weakness
• Irritability
• Blurred vision
• Lower back pain
• Tremors
• Increased appetite
• Change in vision
• Dry mouth
• Weight gain

This medicine is not recommended for pregnant and breastfeeding women unless necessary. 

This medicine may increase the risk of suicidal thoughts in the first week of the treatment.

Gabapentin may cause skin reaction like Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).

Gabapentin is known to cause sedation and dizziness. 

This medicine is known to cause central nervous system effects like behavior changes, difficulty in concentration and restlessness. 

Gabapentin should not be stopped immediately without informing the doctor due to the risk of increasing seizure frequency.

• It is an essential cofactor for many enzymes related to energy metabolism, and activates the insulin-signaling cascade to help lower blood sugar.
• Alpha-lipoic converts blood sugar (glucose) into energy using oxygen, a process referred to as aerobic metabolism. Alpha-lipoic acid is also considered an antioxidant, meaning that it can neutralize harmful compounds called free radicals that damage cells at the genetic level.

• It has long been presumed that alpha-lipoic acid can aid in the control of glucose by increasing the speed in which the blood sugar is metabolized. This could potentially aid in the treatment of diabetes
• It is believed by some that alpha-lipoic acid can effectpeople with diabetic neuropathy,
• Alpha-lipoic acid's ability to enhance calorie burning and promote weight loss has been exaggerated by many diet gurus and supplements manufacturers. 
• Alpha-lipoic acid has long been believed to influence weight and health by altering the lipid (fat) composition in the blood.
• Cosmetics manufacturers often like to boast that their products benefit from the anti-aging properties of alpha-lipoic acid.

•  Nausea,
•  Abdominal pain,
•  Allergic reaction,
•  Diarrhea,
•  Vertigo,
•  Vomiting
•  muscle cramp,
•  a tingling "pins and needles" sensation.

• Food decreases the amount of alpha lipoic acid in the body; hence it should be taken on empty stomach about 1 hour before or 2 hours after consuming food.
• Do not take alpha lipoic acid supplements on your own and as a sole treatment for diabetes, complications of diabetes and other conditions in which benefit may be claimed, as these diseases require proper medical treatment.