• L-Threonine is a precursor to the amino acids glycine and serine. It acts as a lipotropic in controlling fat build-up in the liver.
• L-Threonine helps to maintain the proper protein balance in the body. It is a precursor to the amino acids glycine and serine. It acts as a lipotropic in controlling fat build-up in the liver.

• L-Threonine makes up collagen, elastin, and enamel protein.
• It aids proper fat metabolism in the liver, helps the digestive and intestinal tracts function more smoothly, and assists in metabolism and assimilation.
• It aids liver and lipotropic function when combined with aspartic acid and methionine.
• May help combat mental illness and may be very useful in indigestion and intestinal malfunctions.
• Also, threonine prevents excessive liver fat.
• Nutrients are more readily absorbed when threonine is present.

• Nausea
• Headache
• Rash
• Upset stomach

• There is some concern that threonine might decrease how well a medication used for Alzheimer's disease works.
• This medication is called memantine (Namenda).

Lysine is an amino acid that acts as a building block for the protein in your body. This amino acid is essential since your body cannot produce it on its own.

• Our body’s need lysine to provide healthy functioning. Since lysine helps your body absorb calcium, it helps you treat anxiety.
• It plays a vital role in fighting diseases. Lysine helps the body produce infection-fighting antibodies, enzymes, hormones, and body tissues.
• Lysine supplements are sometimes used to treat a wide range of conditions, including Canker sores, Diabetes, High triglyceride levels, improved muscle strength and athletic performance, Bedsores, Schizophrenia.

• Diarrhoea
• Abdominal Pain
• Chronic Kidney (Renal) Failure
• Inflammation in the Kidney (Interstitial Nephritis)
• Increased Calcium Absorption

• Lysine supplements are possibly safe for most people when taken by mouth in appropriate doses for up to one year or when applied to the skin for up to one year.
• Certain people should avoid the supplement.
• There is not enough evidence to know if it is safe for women who are pregnant or breastfeeding.
• Also, those with kidney disease, intolerance to lysinuric protein, or osteoporosis should speak to their healthcare provider when taking the supplement.

L-Histidine hydrochloride is the obligate precursor of histamine, which is produced via the decarboxylation of the amino acid. It may increase tissue histamine levels increase as the amount of dietary L-histidine increases. Histamine is known to possess immunomodulatory and antioxidant activity.

• Histidine is an α-amino acid that is used in the biosynthesis of proteins.
• It is used in the treatment of nutritional deficiencies.
• L-histidine may be indicated for use in some with rheumatoid arthritis.
• It is not indicated for the treatment of anaemia or uremia or for lowering serum cholesterol.

• Histidine might be safe for most people.
• Doses of up to 4 grams per day have been used in research without causing noticeable side effects.

• Pregnancy and breast-feeding: Not enough is known about the use of histidine during pregnancy and breast-feeding. Stay on the safe side and avoid use.
• Folic acid deficiency: If you have this condition, don't use histidine. It can cause an unwanted chemical called Formiminoglutamic Acid (FIGLU) to build up in the body.

Alpha ketoanalogue belongs to a class of drugs called as nutritional supplements. It follows same catabolic pathways as amino acids and works by improving the metabolism of protein in the body thereby improving the renal function.

•  Alpha Ketoanalogue is most commonly used as nutrition therapy or dietary supplements in the patients of chronic kidney failure. This medicine prevents the unnecessary increase in urea levels in the blood due to the intake of non- essential amino acids in patients of kidney failure.
• This medicine is used in the treatment of diabetic nephropathy to slow down the progression of renal failure.
• It also helps in reducing insulin resistance and improves glycemic control.

• Hypercalcemia - This medicine should be used with caution since it may increase the risk of increased calcium levels in the body.
•  Protein Intake - Patients are advised to take a limited protein intake of not more than 40 grams per day while receiving this medicine.

• Taking it along with a low-protein diet helps in delaying the progression of kidney diseases and dialysis initiation.
• Ensure that you maintain adequate calorie intake during therapy.
•  Regularly monitor serum calcium levels as instructed by your doctor.
•  Reduce your intake of vitamin D and other calcium sources if the levels are high.