• METHYLSULFONYLMETHANE (MSM) is an herbal product or dietary supplement.
• Methyl Sulfonyl Methane is a non-steroidal anti-inflammatory drugs (NSAID). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Some believe that the substance can treat a wide range of health problems, mostnotably arthritis.

Methylsulfonylmethane is used in the treatment of various conditions such as osteoarthritis, tendinitis, musculoskeletal pain, rheumatoid arthritis etc. It is generally used in combination with other medicines for a more effective treatment.

• Diarrhea or constipation
•  Nausea
•  Bloating
•  Headache
•  Fatigue
•  Insomnia

• Take it with food or milk to prevent upset stomach.
•  Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems.
•  Inform your doctor if you have a history of heart disease or stroke.
•  Avoid consuming alcohol while taking Methyl Sulfonyl Methane as it can increase your risk of stomach problems.
•  Your doctor may regularly monitor your kidney function, liver function and levels of blood components if you are taking this medicine for long-term treatment.
•  This supplement is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Ornithine is an amino acid that belongs to the class of medications called as
nutritional supplements. It works by increasing the efficiency of energy
consumption and promoting the excretion of ammonia. It is also known to increase
human growth hormone levels. .

Ornithine is used in the treatment of nutritional deficiencies.
Ornithine by mouth might reduce fatigue and improve measures of athletic
performance such as speed, strength, and power in some people. Also, taking
ornithine in combination with arginine seems to improve strength and power in
male weightlifters.

Allergic reaction
Ornithine is POSSIBLY SAFE when taken by mouth at doses of up to 500 mg daily for
up to 8 weeks.

 Always take ornithine before bedtime and on empty stomach.
 Seek immediate medical attention if you experience any allergic reactions.
 Tell your doctor if you are pregnant, planning to become pregnant or are
breastfeeding.
 Do not take if patient is allergic to ornithine or any of its ingredients.

• Chondroitin sulfate is a chemical that is normally found in cartilage around joints in the body. Chondroitin sulfate is usually manufactured from animal sources, such as shark and cow cartilage.
• It is often used in combination with other ingredients, including manganese ascorbate, glucosamine sulfate, glucosamine hydrochloride, or N-acetyl glucosamine.

• Chondroitin is used for osteoarthritis.  
• Chondroitin sulfate is also taken by mouth for HIV/AIDS, heart disease, heart attack, weak bones (osteoporosis), joint paincaused by drugs used to treat breast cancer, acid reflux, high cholesterol, muscle soreness after exercise, a bladder condition called interstitial cystitis, a bone disease called Kashin-Beck disease, and itchy and scaly skin (psoriasis). Chondroitin sulfate is also used in a complex with iron for treating iron-deficiency anemia.
   

•  Rash,
•  Headache,
•  Diarrhea,
•  Upset stomach,
•  Flatulence

Do not take chondroitin and consult your doctor:

•  If you have allergies, asthma, or prostate cancer.
•  If you have bleeding disorders or diabetes.
•  If you are taking blood thinners.
•  If you are pregnant or breastfeeding.

Glucosamine is a proteoglycan synthesis stimulator which relieves osteoarthritis symptoms. It helps in the formation of cartilage (the soft tissue that cushions the joints) and keep the joints lubricated for better movement and flexibility.
 

•  Glucosamine sulfate are often used as natural remedies for osteoarthritis.
• Glucosamine sulfate can help control osteoarthritis by protecting against the breakdown of cartilage. 
• Glucosamine is touted as a natural remedy for interstitial cystitis, temporomandibular joint disorder, and glaucoma.

•  bloating
•  constipation
•  diarrhea
•  gas
•  heartburn
•  indigestion
•  nausea
•  stomach upset

In rare cases, use of glucosamine may cause such side effects as drowsiness, skin
reactions, vomiting, headache, elevated blood pressure and heart rate, and
palpitations.

•  Do not take glucosamine, if you are allergic to glucosamine or shell fish.
•  Avoid taking glucosamine, if you are pregnant or breast feeding.
•  Doctor’s advice should be considered in case of patients with following history of disease conditions: diabetes; high cholesterol or triglycerides; cancer; liver disease; asthma or breathing disorder.
•  Do not continue the glucosamine, if you are having surgery.

Vitamin C consists of a water-soluble vitamin known as vitamin C. Vitamin C is also known as L-ascorbic acid or ascorbate.  It occurs as a white or slightly yellow crystal or powder with a slightly acidic taste. On exposure to light, it gradually darkens. In the dry state, it is reasonably stable in air, but in solution, it rapidly oxidizes.

• Vitamin C helps in the growth and repair of tissues of bones, cartilage, tendons, skin, hair, muscles and many more.
• Along with that, it helps in wound healing and also enhances the absorption of iron in our body.
• Excess of free radicals can speed up the ageing process, vitamin C due to its rich antioxidant properties help to reduce the harmful effects of these free radicals. Vitamin C is very crucial for bone and teeth health.
• It improves vision and also regulates blood cholesterol levels.
• Owing to its numerous benefits, it is very important to take an adequate amount of vitamin C in your diet.

Possibly Effective for

• An eye disease that leads to vision loss in older adults (age-related macular degeneration or AMD).
• Irregular heartbeat (atrial fibrillation). Taking vitamin C before and for a few days after heart surgery helps prevent irregular heartbeat after heart surgery.
• Emptying the colon before a colonoscopy.
• Limb pain that usually occurs after an injury (complex regional pain syndrome). 
• Skin redness caused by injury or irritation (erythema). Using a skin cream containing vitamin C might decrease skin redness following laser resurfacing for scar and wrinkle removal.
• Airway infections caused by exercise. Using vitamin C before heavy physical exercise, such as a marathon, might prevent upper airway infections that can occur after heavy exercise.
• Swelling (inflammation) of the stomach (gastritis). Some medicine used to treat H. pylori infection can worsen stomach inflammation. Taking vitamin C along with one of these medicines called omeprazole might decrease this side effect.
• A condition in which red blood cells are broken down faster than they are made (hemolytic anemia). Taking vitamin C supplements might help manage anemia in people undergoing dialysis.
• High cholesterol. Taking vitamin C might reduce low-density lipoprotein cholesterol in people with high cholesterol.
• Lead poisoning. Consuming vitamin C in the diet seems to lower blood levels of lead.
• Osteoarthritis. Taking vitamin C from dietary sources or from calcium ascorbate supplements seems to prevent cartilage loss and worsening of symptoms in people with osteoarthritis.
• Pain after surgery. Taking 2 grams of vitamin C by mouth one hour before surgery might reduce pain and the need for opioid pain relievers after surgery. 
• Wrinkled skin. Skin creams containing vitamin C seem to improve the appearance of wrinkled skin. A vitamin C patch also seems to help reduce wrinkles.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Vitamin C and call your doctor at once if you have:

• Joint pain, weakness or tired feeling, weight loss, stomach pain;
• Chills, fever, increased urge to urinate, painful or difficult urination; or
• Severe pain in your side or lower back, blood in your urine.

Common side effects may include:

• Heartburn, upset stomach; or

• Nausea, diarrhoea, stomach cramps.

• Transient mild soreness may occur at the site of intramuscular or subcutaneous injection.
• Too-rapid intravenous administration of the solution may cause temporary faintness or dizziness.
• Although vitamin C is generally considered safe, high doses can cause adverse effects, including heartburn, nausea, headaches, stomach cramps, and diarrhoea.
• Vitamin C is not stored in the body. If you take more than you need, the extra vitamin C will pass into your urine.
• Very large doses may also interfere with tests for sugar in diabetics and with tests for blood in the stool.

• Vitamin E is essential to the normal functioning of the human body. It plays a central role in your immune system and functions as an antioxidant, neutralizing free radicals that damage cells at the genetic level.
• Vitamin E is fat-soluble, meaning that it is dissolved in fat and able to be stored in the liver and fatty tissues of the body.
   

• Vitamin E acts as an antioxidant (i.e., an inhibitor of oxidation processes) in body tissues. It protects unsaturated fats in the body from oxidation by peroxides and other free radicals.  It also acts as an protection of polyunsaturated fatty acids, cell membranes.
• The vitamin is used commercially as an antioxidant to retard the rancidification of fats, especially vegetable oils.
• Vitamin E aids in the transmission of electrical signals between nerve cells (neurons) of the brain and body.
• Vitamin E is integral to eye health, aiding in the self-repair of the retina, cornea, and uvea (the pigmented portion of the eye).
• Vitamin E can aid in scar healing by hydrating the skin, inhibiting collagen production, and reducing inflammation that can lead to tissue damage.
   

Vitamin E supplements rarely cause any harm if taken at the recommended daily dose.
But sometimes lower doses can trigger side effects like

•  nausea,
•  vomiting,
•  stomach pain,
•  diarrhea.
•  Slow down blood clotting

• Vitamin E deficiency is considered rare in the developed world, except in premature babies with low birth weight or in people with rare genetic disorders such as abetalipoproteinemia or ataxia with vitamin E deficiency.
• VitaminE can neither treat nor prevent liver disease but may help slow its progression.
• VitaminE can slow blood clotting and may need to be avoided in people taking blood thinners like Coumadin (warfarin) or Plavix (clopidogrel).
• VitaminE supplements should also be avoided in people with a history of heart attacks, stroke, bleeding disorders, or head and neck cancers.
• VitaminE supplements are presumed to be safe during pregnancy and breastfeeding.

Biotin is a B complex vitamin used as a nutritional supplementation for dietary shortage or imbalance which may cause hair loss or total alopecia, brittle nails, skin rash in infants, and mild depression.

Biotin is a form of vitamin B that provides essential nutrients.

Major & minor side effects for Biotin

• Hypersensitivity
• Stomach discomfort and pain
• Skin rash

This medicine is considered safe for consumption by pregnant and breastfeeding women.

Use of this medicine in children should be done only under your doctor's supervision.

The effect of therapy with Biotin may occur 3 to 6 months after starting the therapy.

Dialysis patients may require a higher dose due to drug removal during dialysis.