• It is an essential cofactor for many enzymes related to energy metabolism, and activates the insulin-signaling cascade to help lower blood sugar.
• Alpha-lipoic converts blood sugar (glucose) into energy using oxygen, a process referred to as aerobic metabolism. Alpha-lipoic acid is also considered an antioxidant, meaning that it can neutralize harmful compounds called free radicals that damage cells at the genetic level.

• Alpha lipoic acid is an antioxidant naturally made by the body.
• It supports normal energy metabolism and helps protect cells from oxidative stress.

•  Nausea,
•  Abdominal pain,
•  Allergic reaction,
•  Diarrhea,
•  Vertigo,
•  Vomiting
•  muscle cramp,
•  a tingling "pins and needles" sensation.

• Food decreases the amount of alpha lipoic acid in the body; hence it should be taken on empty stomach about 1 hour before or 2 hours after consuming food.
• Do not take alpha lipoic acid supplements on your own and as a sole treatment for diabetes, complications of diabetes and other conditions in which benefit may be claimed, as these diseases require proper medical treatment.

• Chromium is a trace mineral that supports normal carbohydrate and fat metabolism.
• It helps maintain healthy blood sugar levels as part of a balanced diet.

• Folic acid is the synthetic form of folate, which is a naturally occurring B vitamin. Folate helps make DNA and other genetic material. It is especially important in prenatal health.
• Folate, also called vitamin B-9, is a B vitamin that naturally occurs in certain foods. Folic acid is the form of folate that manufacturers add to vitamin supplements and fortified foods.

• Folic acid is a B vitamin that helps the body make healthy new red blood cells.
• It supports normal cell growth and is especially important before and during pregnancy.
• Health authorities recommend adequate folic acid intake for women who are or may become pregnant; follow your doctor's advice on the dose.

Skin reactions, seizures, gases problem, diarrhea, irritability, confusion, stomach upset, loss of appetite, and hypersensitivity

It is important to note that folic acid can interact with certain medications.

A person should speak to a doctor before taking folic acid if they have any of the following:

• Epilepsy
• Type 2 diabetes
• Rheumatoid arthritis
• Lupus
• Inflammatory bowel disease (ibd)
• Celiac disease

People undergoing kidney dialysis may also wish to avoid taking folic acid.

• Methylcobalamin/Mecobalamin is a form of vitamin B12 that helps maintain normal vitamin B12 levels in the body, supporting nerve health and red blood cell formation.

• Methylcobalamin is an active form of vitamin B12.
• It supports healthy nerve function and normal red blood cell formation.
• Used as a supplement when dietary intake of vitamin B12 is low.

• Nausea and vomiting
• Diarrhoea
• Decreased appetite
• Dizziness
• Headache
• Skin rash
• Chest pain and discomfort

• Methylcobalamin can show some serious side effects in patients who might suffer from other conditions.
• Everyone needs to consume this medicine only after clinical consultation. The serious side effects of Methylcobalamin can include the formation of clots in limbs, depleted levels of potassium in the blood, a buildup of fluid in the lungs, heart failure and in some cases, anaphylactic reactions such as swollen tongue and throat, and hives.
• Consuming Methylcobalamin is not advisable for patients suffering from optic atrophy, which is a nerve condition that affects the eye.
• People who are suffering from infections or patients who have a low iron level in their body should be careful before taking Methylcobalamin and should only do so after the consultation of the doctor.
• It is not advised for mothers to consume Methylcobalamin if they are breastfeeding. Mother’s milk is a rich source of Vitamin B12 and consuming additional supplements while breastfeeding can have adverse effects on the baby.

Selenium is effective for preventing selenium deficiency.

Selenium might also help improve mood, general feelings of well-being, and quality of life in people with this condition.

Adding salt enriched with selenium to food can prevent Kashin-Beck disease in children.

Pregnant women with low levels of selenium in the blood might have a higher chance of developing pre-eclampsia.

Selenium is a mineral found in soil, water, and some foods. It is important for making many body processes work correctly.

High dosage of selenium dioxide may cause

• Muscle tenderness
• Tremor
• Lightheadedness
• Facial flushing
• Nausea
• Vomiting
• Loss of energy
• Nail changes
• Hair loss
• Irritability
• Garlic breath odor
• A metallic taste

Selenium is unsafe when taken by mouth in high doses or for a long time. 

Selenium is safe during pregnancy and breast-feeding when used short-term in amounts

Selenium is safe for children when taken by mouth appropriately.

selenium might make autoimmune disease worse by stimulating the activity of the disease. 

Blood levels of selenium can be low in people undergoing hemodialysis.

Taking selenium can worsen hypothyroidism especially in people with iodine deficiency.

Selenium might decrease the ability of sperm to move, which could reduce fertility.

Long-term use of selenium supplements might slightly increase the risk of skin cancer recurrence, but this is controversial.

Selenium might increase the risk of bleeding during and after surgery.