Eicosapentaenoic acid is used in combination with docosahexaenoic acid (DHA) in fish oil preparations for a variety of conditions, including preventing and reversing heart disease, and decreasing irregular heartbeats; as well as asthma, cancer, menstrual problems, hot flashes, hay fever, lung diseases, lupus, and kidney disease caused by an immune reaction.

The combination is also used for migraine headache prevention in adolescents, skin infections, Behçet's syndrome, high cholesterol, high blood pressure, psoriasis, Raynaud's syndrome, rheumatoid arthritis, Crohn's disease, and ulcerative colitis.

Eicosapentaenoic acid is long-chain n-3 polyunsaturated fatty acids, which compete with arachidonic acid for inclusion in cyclo-oxygenase and lipoxygenase pathways.

It's actions include hypolipidaemic action (especially a reduction in plasma triglycerides) by reducing very-low-density lipoproteins; anti-inflammatory action, attributed to effects on leukotriene synthesis; and antiplatelet effect, attributed to effects on prostanoid synthesis, which promote vasodilatation, reduction in platelet aggregation, increased bleeding time and decreased platelet counts.

• Nausea
• Gastrointestinal discomfort
• Burping
• Vomiting
• Joint,back and muscle pain
• Diarrhea
• Nosebleed

When used in amounts greater than 3 grams per day, eicosapentaenoic acid can thin the blood and increase the risk for bleeding.

If you are sensitive to aspirin, eicosapentaenoic acid might affect your breathing.

Eicosapentaenoic acid might lower blood pressure.

Omega-3 fatty acids can improve your cardiovascular health.

Omega-3 fatty acids are a type of fat the body cannot make on its own. They are an essential fat, which means they are needed to survive.

Major &Minor side effects of Omega -3 fatty acid

• Raise levels of high-density lipoprotein (HDL/“good” cholesterol).
• Lower blood pressure.
• burping.
• heartburn.
• stomach pain or discomfort.
• joint pain.
• vomiting.
• constipation.
• diarrhea.
• nausea.

Before taking omega-3 fatty acids, tell your doctor if you are allergic to them; or to fish; or if you have any other allergies.

This product may contain inactive ingredients (such as peanut/soy), which can cause allergic reactions or other problems.

During pregnancy, this medication should be used only when clearly needed.