Eicosapentaenoic acid is used in combination with docosahexaenoic acid (DHA) in fish oil preparations for a variety of conditions, including preventing and reversing heart disease, and decreasing irregular heartbeats; as well as asthma, cancer, menstrual problems, hot flashes, hay fever, lung diseases, lupus, and kidney disease caused by an immune reaction.

The combination is also used for migraine headache prevention in adolescents, skin infections, Behçet's syndrome, high cholesterol, high blood pressure, psoriasis, Raynaud's syndrome, rheumatoid arthritis, Crohn's disease, and ulcerative colitis.

Eicosapentaenoic acid is long-chain n-3 polyunsaturated fatty acids, which compete with arachidonic acid for inclusion in cyclo-oxygenase and lipoxygenase pathways.

It's actions include hypolipidaemic action (especially a reduction in plasma triglycerides) by reducing very-low-density lipoproteins; anti-inflammatory action, attributed to effects on leukotriene synthesis; and antiplatelet effect, attributed to effects on prostanoid synthesis, which promote vasodilatation, reduction in platelet aggregation, increased bleeding time and decreased platelet counts.

• Nausea
• Gastrointestinal discomfort
• Burping
• Vomiting
• Joint,back and muscle pain
• Diarrhea
• Nosebleed

When used in amounts greater than 3 grams per day, eicosapentaenoic acid can thin the blood and increase the risk for bleeding.

If you are sensitive to aspirin, eicosapentaenoic acid might affect your breathing.

Eicosapentaenoic acid might lower blood pressure.

DHA is used as a supplement for premature babies and as an ingredient in baby formula during the first year of life to promote better mental development. It is also used in infant formula to prevent lung diseases, allergic diseases such as eczema or hay fever, and diarrhea.

In some cases, DHA is used in combination with arachidonic acid.

DHA is also taken by mouth alone or along with EPA to improve mental function in healthy people or those with mental impairment.

It is also used to improve mental function in people with dementia or age-related mental decline.

 It is also taken by mouth for attention deficit-hyperactivity disorder (ADHD), depression, aggressive behavior, Alzheimer's disease, autism, and to prevent relapse in schizophrenic patients who stop taking antipsychotic medication.

Docosahexaenoic acid (DHA) belongs to the class of medications called as nutritional supplements. DHA plays a vital role in the brain development. DHA decreases cholesterol and triglyceride levels, inhibits platelet aggregation and oxidation of LDL, decreases the synthesis of inflammatory markers such as prostaglandins. Overall, DHA plays a vital role in reducing the heart and circulatory disease risks.

Major & minor side effects for Docosahexaenoic acid

• Bad breath
• Heartburn
• Nausea
• Weight gain
• Allergy

Seek immediate medical attention if you experience any allergic symptoms.

Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding.

Do not take if allergic to DHA or any of its ingredients.

Do not take if having problem with aspirin-sensitivity and hypertension.

Do not take if allergic to fish products.

Vitamin C consists of a water-soluble vitamin known as vitamin C. Vitamin C is also known as L-ascorbic acid or ascorbate.  It occurs as a white or slightly yellow crystal or powder with a slightly acidic taste. On exposure to light, it gradually darkens. In the dry state, it is reasonably stable in air, but in solution, it rapidly oxidizes.

• Vitamin C helps in the growth and repair of tissues of bones, cartilage, tendons, skin, hair, muscles and many more.
• Along with that, it helps in wound healing and also enhances the absorption of iron in our body.
• Excess of free radicals can speed up the ageing process, vitamin C due to its rich antioxidant properties help to reduce the harmful effects of these free radicals. Vitamin C is very crucial for bone and teeth health.
• It improves vision and also regulates blood cholesterol levels.
• Owing to its numerous benefits, it is very important to take an adequate amount of vitamin C in your diet.

Possibly Effective for

• An eye disease that leads to vision loss in older adults (age-related macular degeneration or AMD).
• Irregular heartbeat (atrial fibrillation). Taking vitamin C before and for a few days after heart surgery helps prevent irregular heartbeat after heart surgery.
• Emptying the colon before a colonoscopy.
• Limb pain that usually occurs after an injury (complex regional pain syndrome). 
• Skin redness caused by injury or irritation (erythema). Using a skin cream containing vitamin C might decrease skin redness following laser resurfacing for scar and wrinkle removal.
• Airway infections caused by exercise. Using vitamin C before heavy physical exercise, such as a marathon, might prevent upper airway infections that can occur after heavy exercise.
• Swelling (inflammation) of the stomach (gastritis). Some medicine used to treat H. pylori infection can worsen stomach inflammation. Taking vitamin C along with one of these medicines called omeprazole might decrease this side effect.
• A condition in which red blood cells are broken down faster than they are made (hemolytic anemia). Taking vitamin C supplements might help manage anemia in people undergoing dialysis.
• High cholesterol. Taking vitamin C might reduce low-density lipoprotein cholesterol in people with high cholesterol.
• Lead poisoning. Consuming vitamin C in the diet seems to lower blood levels of lead.
• Osteoarthritis. Taking vitamin C from dietary sources or from calcium ascorbate supplements seems to prevent cartilage loss and worsening of symptoms in people with osteoarthritis.
• Pain after surgery. Taking 2 grams of vitamin C by mouth one hour before surgery might reduce pain and the need for opioid pain relievers after surgery. 
• Wrinkled skin. Skin creams containing vitamin C seem to improve the appearance of wrinkled skin. A vitamin C patch also seems to help reduce wrinkles.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Vitamin C and call your doctor at once if you have:

• Joint pain, weakness or tired feeling, weight loss, stomach pain;
• Chills, fever, increased urge to urinate, painful or difficult urination; or
• Severe pain in your side or lower back, blood in your urine.

Common side effects may include:

• Heartburn, upset stomach; or

• Nausea, diarrhoea, stomach cramps.

• Transient mild soreness may occur at the site of intramuscular or subcutaneous injection.
• Too-rapid intravenous administration of the solution may cause temporary faintness or dizziness.
• Although vitamin C is generally considered safe, high doses can cause adverse effects, including heartburn, nausea, headaches, stomach cramps, and diarrhoea.
• Vitamin C is not stored in the body. If you take more than you need, the extra vitamin C will pass into your urine.
• Very large doses may also interfere with tests for sugar in diabetics and with tests for blood in the stool.

• Vitamin E is essential to the normal functioning of the human body. It plays a central role in your immune system and functions as an antioxidant, neutralizing free radicals that damage cells at the genetic level.
• Vitamin E is fat-soluble, meaning that it is dissolved in fat and able to be stored in the liver and fatty tissues of the body.
   

• Vitamin E acts as an antioxidant (i.e., an inhibitor of oxidation processes) in body tissues. It protects unsaturated fats in the body from oxidation by peroxides and other free radicals.  It also acts as an protection of polyunsaturated fatty acids, cell membranes.
• The vitamin is used commercially as an antioxidant to retard the rancidification of fats, especially vegetable oils.
• Vitamin E aids in the transmission of electrical signals between nerve cells (neurons) of the brain and body.
• Vitamin E is integral to eye health, aiding in the self-repair of the retina, cornea, and uvea (the pigmented portion of the eye).
• Vitamin E can aid in scar healing by hydrating the skin, inhibiting collagen production, and reducing inflammation that can lead to tissue damage.
   

Vitamin E supplements rarely cause any harm if taken at the recommended daily dose.
But sometimes lower doses can trigger side effects like

•  nausea,
•  vomiting,
•  stomach pain,
•  diarrhea.
•  Slow down blood clotting

• Vitamin E deficiency is considered rare in the developed world, except in premature babies with low birth weight or in people with rare genetic disorders such as abetalipoproteinemia or ataxia with vitamin E deficiency.
• VitaminE can neither treat nor prevent liver disease but may help slow its progression.
• VitaminE can slow blood clotting and may need to be avoided in people taking blood thinners like Coumadin (warfarin) or Plavix (clopidogrel).
• VitaminE supplements should also be avoided in people with a history of heart attacks, stroke, bleeding disorders, or head and neck cancers.
• VitaminE supplements are presumed to be safe during pregnancy and breastfeeding.

• Beta-carotene is a pro- vitamin, which is converted in the body to vitamin A, which is necessary for healthy eyes and skin.
• A lack of vitamin A may cause a rare condition called night blindness (problems seeing in the dark). It may also cause dry eyes, eye infections, skin problems, and slowed growth.

• Beta-carotene is a powerful anti-oxidant and prevents the body cells from oxidative damage by free radicals and help build a strong immune system.
• The antioxidant long linked to healthy vision, is now believed to benefit heart health, boost immunity and lower risk of diabetes.
• Beta-carotene along with Vitamin C and E is found to protect skin from harmful radiations of sun preventing from sunburn.
•  High intakes of beta-carotene and vitamin C have been found to increase the lung capacity, relieve respiratory problems, and protect you from breathing disorders such as asthma and bronchitis.

•  Yellowing of palms, hands, or soles of feet, and to a lesser extent the face (this may be a sign that your dose of beta-carotene as a nutritional supplement is too high)
•  Rare
•  Diarrhea
•  dizziness
•  joint pain
•  unusual bleeding or bruising

The advantage of dietary beta-carotene is that the body only converts as much as it needs. Excess Vitamin A can be toxic and harmful. Toxic levels can occur if you consume high doses of supplements without doctor’s consent.