• Folic acid is the synthetic form of folate, which is a naturally occurring B vitamin. Folate helps make DNA and other genetic material. It is especially important in prenatal health.
• Folate, also called vitamin B-9, is a B vitamin that naturally occurs in certain foods. Folic acid is the form of folate that manufacturers add to vitamin supplements and fortified foods.

• It helps the body make healthy new red blood cells.
• In its deficiency a person can develop anemia, leading to fatigue, weakness, and a pale complexion.
• It leads to folate deficiency anemia.
• Folate is also important for the synthesis and repair of DNA and other genetic material.
• It is particularly important to get during pregnancy. Folate deficiency during pregnancy can lead to neural tube irregularities, such as spina bifida and anencephaly.
• Folic acid is crucial for early fetal development.
• Neural tube irregularities - Taking folic acid supplements before and during pregnancy will help prevent neural tube irregularities in the fetus.
• It may also reduce the risks of preterm birth, heart irregularities, and cleft palate, among other things.
• Depression - Taking folic acid supplements could make depression medications more effective.
• The Office on Women’s Health recommend that women who are or might become pregnant take 400–800 mcg of folic acid per day, and that people with spina bifida or a family history of neural tube irregularities take 4,000 mcg per day. Those who are breastfeeding should aim to take around 500 mcg per day.
• The body absorbs folic acid from supplements and fortified foods better than the folate from naturally occurring foods.

Skin reactions, seizures, gases problem, diarrhea, irritability, confusion, stomach upset, loss of appetite, and hypersensitivity

It is important to note that folic acid can interact with certain medications.

A person should speak to a doctor before taking folic acid if they have any of the following:

• Epilepsy
• Type 2 diabetes
• Rheumatoid arthritis
• Lupus
• Inflammatory bowel disease (ibd)
• Celiac disease

People undergoing kidney dialysis may also wish to avoid taking folic acid.

L-Histidine hydrochloride is the obligate precursor of histamine, which is produced via the decarboxylation of the amino acid. It may increase tissue histamine levels increase as the amount of dietary L-histidine increases. Histamine is known to possess immunomodulatory and antioxidant activity.

• Histidine is an α-amino acid that is used in the biosynthesis of proteins.
• It is used in the treatment of nutritional deficiencies.
• L-histidine may be indicated for use in some with rheumatoid arthritis.
• It is not indicated for the treatment of anaemia or uremia or for lowering serum cholesterol.

• Histidine might be safe for most people.
• Doses of up to 4 grams per day have been used in research without causing noticeable side effects.

• Pregnancy and breast-feeding: Not enough is known about the use of histidine during pregnancy and breast-feeding. Stay on the safe side and avoid use.
• Folic acid deficiency: If you have this condition, don't use histidine. It can cause an unwanted chemical called Formiminoglutamic Acid (FIGLU) to build up in the body.

Phenylalanine is used for depression, attention deficit-hyperactivity disorder (ADHD), Parkinson's disease, chronic pain, osteoarthritis, rheumatoid arthritis, alcohol withdrawal symptoms, and a skin disease called vitiligo.

Some people apply it directly to the skin for vitiligo

Phenylalanine is an amino acid, a "building block" of protein. L-phenylalanine is an essential amino acid and is the only form of phenylalanine found in proteins.

The amount of this amino acid found in foods should not pose a risk for otherwise healthy individuals.

This medicine can be consumed by pregnant and breastfeeding women unless absolutely necessary in a certain quantity.

 Phenylalanine should be avoided in people with certain inherited disorders that cause their bodies to build up too much phenylalanine.

People with this disorder can develop mental retardation, high blood pressure, stroke, and many other serious health issues if they consume phenylalanine. 

Lysine is an amino acid that acts as a building block for the protein in your body. This amino acid is essential since your body cannot produce it on its own.

• Our body’s need lysine to provide healthy functioning. Since lysine helps your body absorb calcium, it helps you treat anxiety.
• It plays a vital role in fighting diseases. Lysine helps the body produce infection-fighting antibodies, enzymes, hormones, and body tissues.
• Lysine supplements are sometimes used to treat a wide range of conditions, including Canker sores, Diabetes, High triglyceride levels, improved muscle strength and athletic performance, Bedsores, Schizophrenia.

• Diarrhoea
• Abdominal Pain
• Chronic Kidney (Renal) Failure
• Inflammation in the Kidney (Interstitial Nephritis)
• Increased Calcium Absorption

• Lysine supplements are possibly safe for most people when taken by mouth in appropriate doses for up to one year or when applied to the skin for up to one year.
• Certain people should avoid the supplement.
• There is not enough evidence to know if it is safe for women who are pregnant or breastfeeding.
• Also, those with kidney disease, intolerance to lysinuric protein, or osteoporosis should speak to their healthcare provider when taking the supplement.

Lycopene is a powerful antioxidant that may help protect cells from damage. Hence, it is used for high blood pressure, high cholesterol, cancer, and many other conditions.

Used to treat prostate cancer, leukoplakia, asthma and heart disease.

Discoloration of the skin - Lycopenemia

•  Avoid if pregnant
•  It might increase the risk of bleeding during and after surgery. Stop using lycopene supplements at least 2 weeks before a scheduled surgery.
•  Those taking medication for low blood pressure should not take lycopene.