• CALCITRIOL is a man-made form of vitamin D. It helps your body keep the proper levels of calcium and phosphorus and maintain healthy bones and teeth.
• It raises Vitamin D levels in your blood. This, in turn, raises calcium levels in your blood by helping you absorb more calcium from your intestine

• Calcitriol is a synthetic version of Vitamin D3 used to treat calciumdeficiency with hypoparathyroidism (decreased functioning of the parathyroid glands) and metabolic bone disease in people with chronic kidney failure.
• Calcitriol is used in the treatment of calcium deficiency and postmenopausal osteoporosis.

• Constipation
• Dry Mouth
• Headache
• Loss Of Appetite
• Metallic Taste
• Stomach Upset
• Allergic Reactions Like Skin Rash, Itching Or Hives, Swelling Of The Face, Lips, Or Tongue
• Bone Pain
• Increased Thirst
• Increased Urination (Especially At Night)
• Irregular Heartbeat, High Blood Pressure
• Redness, Blistering, Peeling Or Loosening Of The Skin, Including Inside The Mouth
• Seizures
• Unexpected Weight Loss
• Unusually Weak Or Tired

• You should not use calcitriol if you have high levels of calcium or vitamin D in your blood, or you have had an allergic reaction to calcitriol or other forms of vitamin D.

Eicosapentaenoic acid is used in combination with docosahexaenoic acid (DHA) in fish oil preparations for a variety of conditions, including preventing and reversing heart disease, and decreasing irregular heartbeats; as well as asthma, cancer, menstrual problems, hot flashes, hay fever, lung diseases, lupus, and kidney disease caused by an immune reaction.

The combination is also used for migraine headache prevention in adolescents, skin infections, Behçet's syndrome, high cholesterol, high blood pressure, psoriasis, Raynaud's syndrome, rheumatoid arthritis, Crohn's disease, and ulcerative colitis.

Eicosapentaenoic acid is long-chain n-3 polyunsaturated fatty acids, which compete with arachidonic acid for inclusion in cyclo-oxygenase and lipoxygenase pathways.

It's actions include hypolipidaemic action (especially a reduction in plasma triglycerides) by reducing very-low-density lipoproteins; anti-inflammatory action, attributed to effects on leukotriene synthesis; and antiplatelet effect, attributed to effects on prostanoid synthesis, which promote vasodilatation, reduction in platelet aggregation, increased bleeding time and decreased platelet counts.

• Nausea
• Gastrointestinal discomfort
• Burping
• Vomiting
• Joint,back and muscle pain
• Diarrhea
• Nosebleed

When used in amounts greater than 3 grams per day, eicosapentaenoic acid can thin the blood and increase the risk for bleeding.

If you are sensitive to aspirin, eicosapentaenoic acid might affect your breathing.

Eicosapentaenoic acid might lower blood pressure.

• Methylcobalamin/Mecobalamin is a form of vitamin B12 that restores its level in the body thereby helping in treating certain anaemias and nerve problems.
• It is required for the integrity of myelin, neuronal function, proper red blood cell formation and DNA synthesis

• It is used to treat Vitamin B12 deficiency in people with Pernicious Anemia.
• It is a beneficial drug to most of the common disorders like cardiovascular disorders, diabetes, anaemia, hyperhomocysteinemia and degenerative disorders.
• Methylcobalamin helps in the synthesis of neuronal lipids, regeneration of axonal nerves and has neuroprotective activity, which promotes neurons to function properly and thus improves Alzheimer disease, Parkinsonism, Dementia and neuropathic syndromes.
• It is an approved treatment for peripheral neuropathy.
• It also helps in balancing the levels of homocysteine, which is produced in excess can cause inflammation of blood vessels.

• Nausea and vomiting
• Diarrhoea
• Decreased appetite
• Dizziness
• Headache
• Skin rash
• Chest pain and discomfort

• Methylcobalamin can show some serious side effects in patients who might suffer from other conditions.
• Everyone needs to consume this medicine only after clinical consultation. The serious side effects of Methylcobalamin can include the formation of clots in limbs, depleted levels of potassium in the blood, a buildup of fluid in the lungs, heart failure and in some cases, anaphylactic reactions such as swollen tongue and throat, and hives.
• Consuming Methylcobalamin is not advisable for patients suffering from optic atrophy, which is a nerve condition that affects the eye.
• People who are suffering from infections or patients who have a low iron level in their body should be careful before taking Methylcobalamin and should only do so after the consultation of the doctor.
• It is not advised for mothers to consume Methylcobalamin if they are breastfeeding. Mother’s milk is a rich source of Vitamin B12 and consuming additional supplements while breastfeeding can have adverse effects on the baby.

• Folic acid is the synthetic form of folate, which is a naturally occurring B vitamin. Folate helps make DNA and other genetic material. It is especially important in prenatal health.
• Folate, also called vitamin B-9, is a B vitamin that naturally occurs in certain foods. Folic acid is the form of folate that manufacturers add to vitamin supplements and fortified foods.

• It helps the body make healthy new red blood cells.
• In its deficiency a person can develop anemia, leading to fatigue, weakness, and a pale complexion.
• It leads to folate deficiency anemia.
• Folate is also important for the synthesis and repair of DNA and other genetic material.
• It is particularly important to get during pregnancy. Folate deficiency during pregnancy can lead to neural tube irregularities, such as spina bifida and anencephaly.
• Folic acid is crucial for early fetal development.
• Neural tube irregularities - Taking folic acid supplements before and during pregnancy will help prevent neural tube irregularities in the fetus.
• It may also reduce the risks of preterm birth, heart irregularities, and cleft palate, among other things.
• Depression - Taking folic acid supplements could make depression medications more effective.
• The Office on Women’s Health recommend that women who are or might become pregnant take 400–800 mcg of folic acid per day, and that people with spina bifida or a family history of neural tube irregularities take 4,000 mcg per day. Those who are breastfeeding should aim to take around 500 mcg per day.
• The body absorbs folic acid from supplements and fortified foods better than the folate from naturally occurring foods.

Skin reactions, seizures, gases problem, diarrhea, irritability, confusion, stomach upset, loss of appetite, and hypersensitivity

It is important to note that folic acid can interact with certain medications.

A person should speak to a doctor before taking folic acid if they have any of the following:

• Epilepsy
• Type 2 diabetes
• Rheumatoid arthritis
• Lupus
• Inflammatory bowel disease (ibd)
• Celiac disease

People undergoing kidney dialysis may also wish to avoid taking folic acid.