Benfotiamine is a derivative of vitamin B1. Derived from thiamine, this medication is
used as a dietary supplement. It helps to raise tissue and blood levels of thiamine,
which then helps to protect the body from any med conditions arising from low
levels of thiamine such as heart and nerve disorders. It also helps against diabetic
neuropathy.The drug is easily absorbed through cell membranes, thus making it
easier for it to be transported to the cells that most require it.

It is used for the treatment and prevention of vitamin B1 deficiency that cannot be
corrected through dietary modifications. It may also be used for the treatment of
neuropathies and cardiovascular disorders caused due to vitamin B1 deficiency. It
may also be used for the treatment of Beriberi and Wernicke's encephalopathy.

 Cough
 Difficulty in swallowing
 Itching and skin rash
 Swelling of face, lips, eyelids, or tongue
 Difficulty in breathing
 Nausea
 Weight gain
 Burning sensation
 Headache
 Sleepiness

This medicine is not recommended for use in pregnant and breastfeeding women
unless necessary.

This medicine may interact with many other medicines and may cause severe
adverse effects.

• It is an essential cofactor for many enzymes related to energy metabolism, and activates the insulin-signaling cascade to help lower blood sugar.
• Alpha-lipoic converts blood sugar (glucose) into energy using oxygen, a process referred to as aerobic metabolism. Alpha-lipoic acid is also considered an antioxidant, meaning that it can neutralize harmful compounds called free radicals that damage cells at the genetic level.

• It has long been presumed that alpha-lipoic acid can aid in the control of glucose by increasing the speed in which the blood sugar is metabolized. This could potentially aid in the treatment of diabetes
• It is believed by some that alpha-lipoic acid can effectpeople with diabetic neuropathy,
• Alpha-lipoic acid's ability to enhance calorie burning and promote weight loss has been exaggerated by many diet gurus and supplements manufacturers. 
• Alpha-lipoic acid has long been believed to influence weight and health by altering the lipid (fat) composition in the blood.
• Cosmetics manufacturers often like to boast that their products benefit from the anti-aging properties of alpha-lipoic acid.

•  Nausea,
•  Abdominal pain,
•  Allergic reaction,
•  Diarrhea,
•  Vertigo,
•  Vomiting
•  muscle cramp,
•  a tingling "pins and needles" sensation.

• Food decreases the amount of alpha lipoic acid in the body; hence it should be taken on empty stomach about 1 hour before or 2 hours after consuming food.
• Do not take alpha lipoic acid supplements on your own and as a sole treatment for diabetes, complications of diabetes and other conditions in which benefit may be claimed, as these diseases require proper medical treatment.

Calcium carbonate is a dietary supplement used when the amount of calcium taken in the diet is not enough. Calcium is needed by the body for healthy bones, muscles, nervous system, and heart. Calcium carbonate also is used as an antacid to relieve heartburn, acid indigestion, and upset stomach. It is available with or without a prescription.

• This medication is used to treat symptoms caused by too much stomach acid such as heartburn, upset stomach, or indigestion.
• It is an antacid that works by lowering the amount of acid in the stomach.

• Constipation, gas, and burping may occur.​​​​​
• Many people using this medication do not have serious side effects.
• Tell your doctor right away if any of these unlikely but serious side effects occur: loss of appetite, nausea/vomiting, unusual weight loss, bone/muscle pain, mental/mood changes (e.g., confusion), headache, increased thirst/urination, unusual weakness/tiredness.

• Before taking calcium carbonate, tell your doctor or pharmacist if you are allergic to it. This product may contain inactive ingredients (such as milk or dairy products found in some brands), which can cause allergic reactions or other problems.
• If you have any of the following health problems, consult      your doctor or pharmacist before using this medication: highypercalcemia, intestinal blockage, kidney disease (such as kidney stones).
• Some products may contain aspartame. If you have phenylketonuria (PKU) or any other condition that requires you to restrict your intake of aspartame (or phenylalanine), consult your doctor or pharmacist about using this drug safely.
• Tell your doctor if you are pregnant before using this medication.
• This medication passes into breast milk. Consult your doctor before breast-feeding.

• Folic acid is the synthetic form of folate, which is a naturally occurring B vitamin. Folate helps make DNA and other genetic material. It is especially important in prenatal health.
• Folate, also called vitamin B-9, is a B vitamin that naturally occurs in certain foods. Folic acid is the form of folate that manufacturers add to vitamin supplements and fortified foods.

• It helps the body make healthy new red blood cells.
• In its deficiency a person can develop anemia, leading to fatigue, weakness, and a pale complexion.
• It leads to folate deficiency anemia.
• Folate is also important for the synthesis and repair of DNA and other genetic material.
• It is particularly important to get during pregnancy. Folate deficiency during pregnancy can lead to neural tube irregularities, such as spina bifida and anencephaly.
• Folic acid is crucial for early fetal development.
• Neural tube irregularities - Taking folic acid supplements before and during pregnancy will help prevent neural tube irregularities in the fetus.
• It may also reduce the risks of preterm birth, heart irregularities, and cleft palate, among other things.
• Depression - Taking folic acid supplements could make depression medications more effective.
• The Office on Women’s Health recommend that women who are or might become pregnant take 400–800 mcg of folic acid per day, and that people with spina bifida or a family history of neural tube irregularities take 4,000 mcg per day. Those who are breastfeeding should aim to take around 500 mcg per day.
• The body absorbs folic acid from supplements and fortified foods better than the folate from naturally occurring foods.

Skin reactions, seizures, gases problem, diarrhea, irritability, confusion, stomach upset, loss of appetite, and hypersensitivity

It is important to note that folic acid can interact with certain medications.

A person should speak to a doctor before taking folic acid if they have any of the following:

• Epilepsy
• Type 2 diabetes
• Rheumatoid arthritis
• Lupus
• Inflammatory bowel disease (ibd)
• Celiac disease

People undergoing kidney dialysis may also wish to avoid taking folic acid.