ISTAMET 500mg is a Fixed Dose Combination medication containing Sitagliptin Phosphate and Metformin Hydrochloride. It is prescribed to manage type 2 diabetes by improving blood sugar control. The synergistic action of Sitagliptin and Metformin helps regulate blood glucose levels by different mechanisms, contributing to better glycemic control in diabetic patients.

• Improving insulin sensitivity
• Control of blood glucose levels
• Type 2 Diabetes Mellitus management
• Enhancing glycemic control

• Headache
• Diarrhea
• Nausea
• Hypoglycemia (low blood sugar)
• Abdominal discomfort

Take ISTAMET 500mg orally with meals as prescribed by your healthcare provider. Do not crush or chew the tablets, swallow them whole with a full glass of water.

• Pregnancy - ISTAMET 500mg should be used during pregnancy only if clearly needed and under the supervision of a healthcare provider.
• Alcohol - Limit alcohol consumption while taking ISTAMET 500mg as it may affect blood sugar control and increase the risk of side effects.
• Old Age - Caution is advised when using ISTAMET 500mg in the elderly population. Dosage adjustments may be required based on renal function.
• Breast Feeding - ISTAMET 500mg should be used with caution while breastfeeding. Consult your doctor before beginning treatment.
• Children - ISTAMET 500mg is not recommended for use in children. Consult a pediatric endocrinologist for alternative treatment options.

• Store at room temperature (20-25°C) -
• Protect from moisture and light -
• Keep out of reach of children -

• Drug-Drug - ISTAMET 500mg may interact with certain medications like insulin secretagogues. Inform your doctor about all the medications you are taking before starting ISTAMET 500mg.
• Drug-Food - Avoid consuming grapefruit or grapefruit juice while taking ISTAMET 500mg as it may alter drug absorption.
• Drug-Disease - Use ISTAMET 500mg with caution in patients with renal impairment or liver disease. Regular monitoring is advised in such cases.

• Q. Can ISTAMET 500mg cause weight gain?
  Weight gain is a less common side effect of ISTAMET 500mg compared to some other diabetes medications. However, individual responses may vary.
• Q. What should I do if I miss a dose of ISTAMET 500mg?
  If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
• Q. Can I stop taking ISTAMET 500mg if my blood sugar is under control?
  Do not stop taking ISTAMET 500mg without consulting your doctor, even if your blood sugar levels are stable. Abruptly stopping medication can lead to fluctuations in blood sugar levels.
• Q. Are there any dietary restrictions with ISTAMET 500mg?
  While on ISTAMET 500mg, it is important to follow a balanced diet recommended by your healthcare provider. Monitor carbohydrate intake to help manage blood sugar levels effectively.
• Q. Is it safe to drive while taking ISTAMET 500mg?
  ISTAMET 500mg may cause dizziness or hypoglycemia in some individuals. If you experience these side effects, avoid driving or operating heavy machinery until you know how the medication affects you.