• Selenium is used in the treatment of natural deficiency.
• Selenium is essential for the conversion of thyroxine (T4) to the biologically active thyroid hormone triiodothyronine (T3) thereby it is important in thyroid hormone functioning.
• Selelium is not produced in the body but is needed for the proper immune system and thyroid function.
• It is found in soil, water and some food.

• Selelium is a powerful mineral. It plays a key role in metabolism and the functioning of the Thyroid glands.
• Selenium has antioxidant properties.
• Selenium is used to cure Prostate cancer.
• Some of the diseases due to deficiency of selelium are HIV, Crohn’s disease.
• It is also used to treat diseases like Asthma, Arthritis, Dandruff and Infertility.

• Selenium deficiency produces biochemical changes that might predispose people who experience additional stresses to develop certain illnesses.
• Side effects may include fingernail loss, skin rash, fatigue, irritability and weight loss.

It is observed that overdose of Selelium may increase the chances of non- melanoma (Skin cancer).

• Magnesium citrate is an osmotic laxative which comes in a liquid form. It is a combination of the element magnesium that is bound to citric acid.
• Magnesium citrate belongs to group of drugs known as saline laxatives, which work by pulling more water into the colon in order to help the colon empty its contents.

• Magnesium Citrate is used for the treatment of constipation.
• It may be used to treat occasional constipation, acid indigestion, or in prescribed amounts, it is used to help clear the large intestine of stool before a test (such as for a colonoscopy), procedure, or operation on the digestive system.

•  Stomach and intestinal issues like gas, diarrhea, nausea, vomiting, andstomach cramping
•  High levels of magnesium in your bloodstream
•  Imbalance in your electrolytes, or levels of minerals and compounds likesodium, potassium, calcium, chloride, and phosphate in your blood

•  If you are allergic to magnesium citrate or any of its inactive ingredients, you should not take magnesium citrate.
•  You should not take magnesium citrate if you are on a low-sodium or restricted-sodium diet.
•  If you suffer from chronic or long-term constipation, you should not take magnesium citrate - it's not safe for daily, long-term, or   frequent treatment of constipation.
• Take it atleast 2 hours after taking other medicines, as it may interfere with the absorption of other medicines.

• Folic acid is the synthetic form of folate, which is a naturally occurring B vitamin. Folate helps make DNA and other genetic material. It is especially important in prenatal health.
• Folate, also called vitamin B-9, is a B vitamin that naturally occurs in certain foods. Folic acid is the form of folate that manufacturers add to vitamin supplements and fortified foods.

• It helps the body make healthy new red blood cells.
• In its deficiency a person can develop anemia, leading to fatigue, weakness, and a pale complexion.
• It leads to folate deficiency anemia.
• Folate is also important for the synthesis and repair of DNA and other genetic material.
• It is particularly important to get during pregnancy. Folate deficiency during pregnancy can lead to neural tube irregularities, such as spina bifida and anencephaly.
• Folic acid is crucial for early fetal development.
• Neural tube irregularities - Taking folic acid supplements before and during pregnancy will help prevent neural tube irregularities in the fetus.
• It may also reduce the risks of preterm birth, heart irregularities, and cleft palate, among other things.
• Depression - Taking folic acid supplements could make depression medications more effective.
• The Office on Women’s Health recommend that women who are or might become pregnant take 400–800 mcg of folic acid per day, and that people with spina bifida or a family history of neural tube irregularities take 4,000 mcg per day. Those who are breastfeeding should aim to take around 500 mcg per day.
• The body absorbs folic acid from supplements and fortified foods better than the folate from naturally occurring foods.

Skin reactions, seizures, gases problem, diarrhea, irritability, confusion, stomach upset, loss of appetite, and hypersensitivity

It is important to note that folic acid can interact with certain medications.

A person should speak to a doctor before taking folic acid if they have any of the following:

• Epilepsy
• Type 2 diabetes
• Rheumatoid arthritis
• Lupus
• Inflammatory bowel disease (ibd)
• Celiac disease

People undergoing kidney dialysis may also wish to avoid taking folic acid.