Coenzyme Q10 is most commonly used for conditions that affect the heart such as heart failure and fluid build up in the body, chest pain, and high blood pressure. It is also used for preventing migraine headache, Parkinson disease, and many other conditions.

Coenzyme Q10 is a vitamin-like substance found throughout the body, but especially in the heart, liver, kidney, and pancreas.

Major &Minor side effects of Coenzyme Q10

• Stomach upset
• Nausea
• Loss of appetite
• Vomiting
• Diarrhea
• Allergic skin rashes
• Low blood pressure

This medicine is safe when taken by mouth appropriately during pregnancy.

This medicine is safe to be taken by children under medical supervision.

People undergoing chemotherapy with a class of drugs called alkylating agents should use coenzyme Q10 with caution.

Coenzyme Q10 might lower blood pressure.

Cigarette smoking depletes the amount of coenzyme Q10 stored by the body.

Coenzyme Q10 might interfere with blood pressure control during and after surgery.

Lycopene is a powerful antioxidant that may help protect cells from damage. Hence, it is used for high blood pressure, high cholesterol, cancer, and many other conditions.

Used to treat prostate cancer, leukoplakia, asthma and heart disease.

Discoloration of the skin - Lycopenemia

•  Avoid if pregnant
•  It might increase the risk of bleeding during and after surgery. Stop using lycopene supplements at least 2 weeks before a scheduled surgery.
•  Those taking medication for low blood pressure should not take lycopene.

• Vitamin E is essential to the normal functioning of the human body. It plays a central role in your immune system and functions as an antioxidant, neutralizing free radicals that damage cells at the genetic level.
• Vitamin E is fat-soluble, meaning that it is dissolved in fat and able to be stored in the liver and fatty tissues of the body.
   

• Vitamin E acts as an antioxidant (i.e., an inhibitor of oxidation processes) in body tissues. It protects unsaturated fats in the body from oxidation by peroxides and other free radicals.  It also acts as an protection of polyunsaturated fatty acids, cell membranes.
• The vitamin is used commercially as an antioxidant to retard the rancidification of fats, especially vegetable oils.
• Vitamin E aids in the transmission of electrical signals between nerve cells (neurons) of the brain and body.
• Vitamin E is integral to eye health, aiding in the self-repair of the retina, cornea, and uvea (the pigmented portion of the eye).
• Vitamin E can aid in scar healing by hydrating the skin, inhibiting collagen production, and reducing inflammation that can lead to tissue damage.
   

Vitamin E supplements rarely cause any harm if taken at the recommended daily dose.
But sometimes lower doses can trigger side effects like

•  nausea,
•  vomiting,
•  stomach pain,
•  diarrhea.
•  Slow down blood clotting

• Vitamin E deficiency is considered rare in the developed world, except in premature babies with low birth weight or in people with rare genetic disorders such as abetalipoproteinemia or ataxia with vitamin E deficiency.
• VitaminE can neither treat nor prevent liver disease but may help slow its progression.
• VitaminE can slow blood clotting and may need to be avoided in people taking blood thinners like Coumadin (warfarin) or Plavix (clopidogrel).
• VitaminE supplements should also be avoided in people with a history of heart attacks, stroke, bleeding disorders, or head and neck cancers.
• VitaminE supplements are presumed to be safe during pregnancy and breastfeeding.

• Folic acid is the synthetic form of folate, which is a naturally occurring B vitamin. Folate helps make DNA and other genetic material. It is especially important in prenatal health.
• Folate, also called vitamin B-9, is a B vitamin that naturally occurs in certain foods. Folic acid is the form of folate that manufacturers add to vitamin supplements and fortified foods.

• It helps the body make healthy new red blood cells.
• In its deficiency a person can develop anemia, leading to fatigue, weakness, and a pale complexion.
• It leads to folate deficiency anemia.
• Folate is also important for the synthesis and repair of DNA and other genetic material.
• It is particularly important to get during pregnancy. Folate deficiency during pregnancy can lead to neural tube irregularities, such as spina bifida and anencephaly.
• Folic acid is crucial for early fetal development.
• Neural tube irregularities - Taking folic acid supplements before and during pregnancy will help prevent neural tube irregularities in the fetus.
• It may also reduce the risks of preterm birth, heart irregularities, and cleft palate, among other things.
• Depression - Taking folic acid supplements could make depression medications more effective.
• The Office on Women’s Health recommend that women who are or might become pregnant take 400–800 mcg of folic acid per day, and that people with spina bifida or a family history of neural tube irregularities take 4,000 mcg per day. Those who are breastfeeding should aim to take around 500 mcg per day.
• The body absorbs folic acid from supplements and fortified foods better than the folate from naturally occurring foods.

Skin reactions, seizures, gases problem, diarrhea, irritability, confusion, stomach upset, loss of appetite, and hypersensitivity

It is important to note that folic acid can interact with certain medications.

A person should speak to a doctor before taking folic acid if they have any of the following:

• Epilepsy
• Type 2 diabetes
• Rheumatoid arthritis
• Lupus
• Inflammatory bowel disease (ibd)
• Celiac disease

People undergoing kidney dialysis may also wish to avoid taking folic acid.

Vitamin B12 is used in the treatment of vitamin B12 deficiency.

Vitamin B12 is a nutrient which the body requires in small amounts to make red blood cells, generate energy, and keep nerve cells healthy.

• Symptoms of Vitamin B12 Deficiency
• Weakness, tiredness, or lightheadedness
• Anemia
• Heart palpitations and shortness of breath
• Pale skin
• A smooth tongue
• Constipation, diarrhea, loss of appetite, or gas 
• Nerve problems like numbness or tingling, muscle weakness, and problems walking
• Vision loss
• Mental problems like depression, memory loss, or behavioral changes 

• Most people can prevent vitamin B12 deficiency by eating enough meat, poultry, seafood, dairy products, and eggs.
• If you don't eat animal products, or you have a medical condition that limits how well your body absorbs nutrients, you can take vitamin B12 in a multivitamin or other supplement and foods fortified with vitamin B12.

Generic Name: cholecalciferol 

Vitamin D3 is needed for normal absorption of calcium and phosphorus, which is further utilized for development and maintenance of bones and teeth. This makes bones stronger and reduces risk for bone fractures.  Vitamin D3 also has a role in ones nerve, muscle, and immune systems.

People who might need extra vitamin D3 include

•  Older adult
•  Breastfed infants
•  People with dark skin
•  People with certain conditions, such as liver diseases, cystic fibrosis and Crohn's disease
•  People who have obesity or have had gastric bypass surgery

Symptoms of vitamin D3 deficiency include bone pain, muscle weakness, fatigue, and mood changes. Vitamin D3 is used for treating osteoporosis, rickets, osteomalacia, renal osteodystrophy and hypoparathyroidism.

•   nausea
•       vomiting
•         constipation
•         weight loss
•        weakness
•         increased calcium levels (hypercalcemia)

May cause allergic reactions or other problems if contain inactive ingredients such as peanut/soy. Pregnant women or Breastfeeding mothers need to consult their doctors before taking Vitamin D3 supplements.