Vitamin B12 is used in the treatment of vitamin B12 deficiency.

Vitamin B12 is a nutrient which the body requires in small amounts to make red blood cells, generate energy, and keep nerve cells healthy.

• Symptoms of Vitamin B12 Deficiency
• Weakness, tiredness, or lightheadedness
• Anemia
• Heart palpitations and shortness of breath
• Pale skin
• A smooth tongue
• Constipation, diarrhea, loss of appetite, or gas 
• Nerve problems like numbness or tingling, muscle weakness, and problems walking
• Vision loss
• Mental problems like depression, memory loss, or behavioral changes 

• Most people can prevent vitamin B12 deficiency by eating enough meat, poultry, seafood, dairy products, and eggs.
• If you don't eat animal products, or you have a medical condition that limits how well your body absorbs nutrients, you can take vitamin B12 in a multivitamin or other supplement and foods fortified with vitamin B12.

• Folic acid is the synthetic form of folate, which is a naturally occurring B vitamin. Folate helps make DNA and other genetic material. It is especially important in prenatal health.
• Folate, also called vitamin B-9, is a B vitamin that naturally occurs in certain foods. Folic acid is the form of folate that manufacturers add to vitamin supplements and fortified foods.

• It helps the body make healthy new red blood cells.
• In its deficiency a person can develop anemia, leading to fatigue, weakness, and a pale complexion.
• It leads to folate deficiency anemia.
• Folate is also important for the synthesis and repair of DNA and other genetic material.
• It is particularly important to get during pregnancy. Folate deficiency during pregnancy can lead to neural tube irregularities, such as spina bifida and anencephaly.
• Folic acid is crucial for early fetal development.
• Neural tube irregularities - Taking folic acid supplements before and during pregnancy will help prevent neural tube irregularities in the fetus.
• It may also reduce the risks of preterm birth, heart irregularities, and cleft palate, among other things.
• Depression - Taking folic acid supplements could make depression medications more effective.
• The Office on Women’s Health recommend that women who are or might become pregnant take 400–800 mcg of folic acid per day, and that people with spina bifida or a family history of neural tube irregularities take 4,000 mcg per day. Those who are breastfeeding should aim to take around 500 mcg per day.
• The body absorbs folic acid from supplements and fortified foods better than the folate from naturally occurring foods.

Skin reactions, seizures, gases problem, diarrhea, irritability, confusion, stomach upset, loss of appetite, and hypersensitivity

It is important to note that folic acid can interact with certain medications.

A person should speak to a doctor before taking folic acid if they have any of the following:

• Epilepsy
• Type 2 diabetes
• Rheumatoid arthritis
• Lupus
• Inflammatory bowel disease (ibd)
• Celiac disease

People undergoing kidney dialysis may also wish to avoid taking folic acid.

• Silicon dioxide, or silica, is a combination of silicon and oxygen, two very abundant, naturally occurring materials.
• There are many forms of silica. They all have the same makeup but may have a different name, depending on how the particles arrange themselves. In general, there are two groups of silica: crystalline silica and amorphous silica.

It is used in the food industry as an additive and anticaking agent. This type of food additive prevents foods from caking or sticking together in clumps. This may help ensure a product’s shelf life, protect against the effects of moisture, and keep powdered ingredients from sticking together and helping them flow smoothly

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• These include nanoparticles, which are silica particles that are much smaller than most of the particles that occur in nature.
• The concern is that these tiny particles could reach different areas of the body and even get into the cells themselves.
• While most people think standard silicon dioxide is generally safe, the EFSA have expressed concerns about using silica nanoparticles in food, as there are no long-term safety studies.